Malaria is a major cause of mortality and morbidity in Sub-Saharan Africa (SSA) and one of the biggest impediments to the economic development of the region. Malaria is transmitted by Anopheles mosquitoes and one of the major methods for controlling these mosquitoes is through the use of chemical insecticides. Insecticide resistance is a major threat to the recent advances the malaria control community has made in reducing both deaths and malaria infections. To reduce the impact of resistance, malaria control programme managers need to know when resistance is emerging in their intervention areas and put in place measures to prevent its spread.
The most effective way of doing this is by using DNA markers which can detect the presence of a resistance associated marker in a mosquito population before it reaches high frequency. It is the primary goal of this proposal to revolutionize the application of molecular markers for insecticide resistance across the malaria endemic countries of SSA by providing control programs with new markers and geographically-calibrated maps that predict their impact on resistance phenotypes.